TMEM37 and viral infectious disease: Furthermore, defense-related genes, such as enhanced disease susceptibility-1 (EDS1) gene up regulation indicated the involvement in salicylic acid (SA) signaling pathway, non-expressor of pathogenesis-related genes-1 (NPR1) involved in mediation of cross talk between SA or jasmonic acid (JA) and ethylene (ET) signaling pathways and induction of SAR in plant system by the activation of PR2B, a PR- protein results in activation of defense against virus infection [240].