Lately, a novel hyperthermia responsive poly(2-((2-methacryloyloxy)ethyl) dimethylammonio)acetyl) (phenylsulfonyl) amide (PMEDAPA)-based NG loaded with DOX and modified with glycoprotein transferrin (Tf) exhibited switchable tumor targeting, and DOX release (chemotherapy) regulated by microwave heating (microwave heating therapy) for effective inhibition of human hepatoma cell line (HepG2) bearing tumor xenograft growth [102]. This evidence concerns the gene TF and neoplasm.