Intriguingly, self-assembled NGs of cholesterol-bearing cycloamylose with spermine groups (for superior transfection) (CH-CA-Spe) were used for intra-tumor delivery of siRNA specific to vascular endothelial growth factor (siVEGF) into renal cell carcinoma (RCC) cells through the endocytotic pathway for treating malignancies by suppressing neo-vascularization [101]. The gene discussed is VEGFA; the disease is renal cell carcinoma.