The main findings of this study were that (1) CCK2R is overexpressed, at both the mRNA and protein level, in mouse DRG following VCR exposure; (2) the blockade of CCK2R by proglumide or Ly225910 is an effective strategy to reduce mechanical allodynia and prevent sensory nerve fiber damage induced by VCR; and (3) proglumide or Ly225910 in combination with VCR did not adversely affect the anticancer activity of VCR in human cancer cell lines. This evidence concerns the gene CCKBR and cancer.