Upon internalization into endothelial cells, EVs bioactive compounds such as miRNA, ncRNA, and proteins that have the potential to initiate an angiogenesis switch targeting various mechanisms such as vascular endothelial growth factor (VEGF)/VEGF receptor, WNT, Notch, and hypoxia-inducing factor, thus contributing to tumour angiogenesis [41,44]. Here, VEGFA is linked to neoplasm.