An ALS mouse model based on C9orf72 repeat expansion (FVB-C9orf72 BAC mouse; C9-BAC) was successfully generated in 2016, with the transgenic mice (C9) exhibiting decreased survival, hind limb paralysis, muscle denervation, and motor neuron loss that is relevant to ALS, especially in females [21]. This evidence concerns the gene C9 and amyotrophic lateral sclerosis.