Like NF-κB, we did not observe an increase in phosphorylation of p38, ERK1/2, and JNK over the course of 48 h in TPA-induced THP-1 macrophage without Zika virus infection, and the basal level patterns of phosphorylated kinases were similar in DMSO and AP-treated groups (Figure S2). Here, MAPK3 is linked to Zika virus infectious disease.