TNF and neoplasm: It was shown that immunosuppressive molecules secreted by tumor cells could promote the secretion of IL-10, IL-6, TNF-α, and COX-2 inflammatory mediators by macrophages, mast cells, tumor-associated fibroblasts, endothelial cells, neutrophils, NK cells, and DCs that are enrolled in the tumor tissue, thus creating a vicious circle that results in tumor cells escaping from the immune system [55].