STAT3 and neoplasm: The activation of STAT3 in mice may reduce the occurrence and malignant progression of Kras (G12D)-driven lung adenocarcinoma by controlling the expression of interleukin 8 (IL-8) induced by nuclear factor kappa-B (NF-κB), and inhibiting IL-8-mediated myeloid tumor infiltration and tumor vascularization [33].