In addition, Herman et al. found that protein tyrosine phosphatase receptor-T (PTPRT) negatively regulated STAT3 function by dephosphorylating STAT3 (Tyr705), and the silence of PTPRT using siRNA in NSCLC led to the increased expression of pSTAT3 (Tyr705) and STAT3 target genes such as cyclin D1 and Bcl-XL [72]. This evidence concerns the gene STAT3 and non-small cell lung carcinoma.