Neuroinflammation is the activation of the immune response in the CNS by microglia and astrocytes, which indigenous immune cells, astrocytes, and microglia lead to the secretion of cytokines, including TNF-α, IL-1β, and IL-6 initiating inflammatory responses; these processes also occur in ischemic stroke [26,27,28,29,30,31,32]. The gene discussed is TNF; the disease is ischemic stroke.