NF-κB activation is initiated when molecules such as TNF-α bind to TNF receptors, and the induction of NF-κB target genes requires phosphorylation of NF-κB proteins, such as p65; therefore, factors that modulate the activity of NF-κB may modulate the inflammatory process in ischemic stroke [33,34,35]. The gene discussed is NFKB1; the disease is ischemic stroke.