Knockdown of malonyl-CoA decarboxylase, an enzyme related to FAO, inhibits monocrotaline (MCT) or hypoxia-induced PAH in mice [103], suggesting that the increased FAO in PAH may be a compensatory pathway for the adaptation of pulmonary vascular cells to energy defects, but it may also be one of the reasons for the proliferation of PASMCs. Here, MLYCD is linked to pulmonary arterial hypertension.