VEGFA and central nervous system cancer: A study that evaluated the association of VEGF and KDR SNPs in patients with severe gliomas showed that VEGFA-2578 C/A and VEGFA-1154G/A increased the risk of severe glioma and that the “CAGT” haplotype of the KDR gene altered the aggressiveness of high-grade glioma and the risk of grade IV tumors [76].