ITGAX and neoplasm: The resulting polyplex micelles were found to have higher LN accumulations than their free formulations following s.c. administration, ultimately leading to a higher expansion of LN-resident DCs (CD45+CD11c+) and macrophages (CD45+F4/80+), and systemic antigen-specific (dextramer+) CD8+ T cells (CD45+CD3+CD8+), and efficient tumor regression [94].