CD8A and neoplasm: This enhancement was found to be conditioned by the presence of LL-37 during DC differentiation, pulsation, and maturation, and to lie in the enhanced ability of such LL-37-treated DCs to induce the expansion of autologous CD8+ T cells with downregulated PD-1 expression and to enrich the expanded cell culture with CD8+ T cells that are reactive to tumor cells expressing antigens used for the pulsation of these DCs.