Furthermore, the bile acid mixtures inhibited OATP1B3-mediated EZE-Ph and estradiol-17β-glucuronide uptake in a concentration-dependent manner, with IC50 values of 15.0 and 21.2 μM, respectively (Figure 10C,D), which are markedly lower than the levels of TBA (51.3 μM) observed in CLD patients [21]. Here, SLCO1B3 is linked to congenital secretory chloride diarrhea 1.