VEGFA and neoplasm: In another study, the PLGA-NPs were loaded with a recombinant human VEGF-A165 (the vascular endothelial growth factor, rhVEGF) analog via the 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) covalent coupling method as a new theranostic technology for tumor diagnosis and therapy by Varani et al. as shown in Figure 8.