VEGFA and neoplasm: Mice that were injected with VEGF-PLGA-NPs represented elevated tumor uptake and higher target-to- muscle (T/M) ratio in comparison with PLGA-NPs, where the tumor uptake and T/M ratio of VEGF-PLGA-NPs were 39.83 ± 7.17 and 7.90 ± 1.61, while for PLGA-NPs they were 29.95 ± 1.92 and 4.49 ± 0.54, respectively [101].