Additionally, the generation of reactive oxygen species (ROS) and interleukin-8 (IL-8) in COPD is suppressed when the antioxidant 1,3-di [5-(N-methylene-pyridinium-4-yl)-10,15,20-triphenylporphynato manganese]-benzene tetrachloride (MnPD) is coupled with PLA NP [160]. The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.