For example, Kim et al. (2019) evaluated the tumor microenvironment of their organoids and found that their cells contained heterogeneous characteristics in terms of the expression of membrane markers; some were a mixture of p63 + cells and p63− cells, others were only CK7+, other organoids were only CK5/6+, and others comprised a mixture of CK7+ and CK5/6+ cells, with different spatial patterns of cell types [174]. The gene discussed is KRT5; the disease is neoplasm.