Due to the specific binding between the Glu ligands and GLUT1, the siPLK1-loaded Glu-Au NPs displayed increased cellular uptake as well as gene silencing efficiency and therefore enhanced anticancer activity both in the GLUT1-overexpressing MDA-MB-231 cell spheroids and MDA-MB-231 orthotropic tumor [171]. This evidence concerns the gene SLC2A1 and neoplasm.