CASP3 and cancer: They accumulated in the mitochondria of MDA-MB-435S cells or vasculogenic mimicry (VM) channel-forming cancer cells, causing acute cytotoxic damage and apoptosis, whereby caspase 9 and caspase 3 were activated and VM channel-forming indicators (MMP-9, EphA2, VE-Cadherin, FAK and HIF-1α) downregulated.