In addition to the decrease of metastatic signal molecules, we surprisingly found several conventionally used internal control molecules including GAPDH, tubulin, cyclophilin B and cofilin were also dramatically suppressed (by 85–95%) in the high-dose (2.0 mg/g mouse) dasatinib-treated HuCCT1 tumor, whereas COX IV and β-actin were suppressed to a much lesser extent (by 25 and 8.0%, respectively). The gene discussed is CFL1; the disease is neoplasm.