Therapeutic potential and neuroprotective effect of curcumin against hippocampal damage with 6-hydroxydopamine (6-OHDA) in Parkinson’s rat model with increased expression of brain-derived neurotrophic factor (BDNF) and phosphatidyl receptor proteins inositol 3-kinase (PI3K), was evaluated and validated by Yang et al. [57]. Here, BDNF is linked to Parkinson disease.