At the same time, the reduction in IL-10 secretion can alleviate the inhibition of IFN-γ and TNF-α secretion [61,62,63], IFN-γ can reduce the number of tumor stem cells, and the increase in IFN-γ level responds to its anti-proliferative, apoptosis-promoting, and antitumor effects [64,65,66], while the increase in TNF-α content indicates the increase in mono-nuclear macrophages in tumor cells [67], which means that LBP increases the antitumor ability of DOX. Here, TNF is linked to neoplasm.