Based on this, researchers [182] developed lipid nanoparticles consisting of G0-C14, PLGA, and lipid PEG and modified them with CTCE-9908, a targeting peptide specific to CXCR4 (which is highly expressed in hepatocellular carcinoma cells) to achieve specific targeting of hepatocellular carcinoma cells. This evidence concerns the gene CXCR4 and hepatocellular carcinoma.