In this study, we employed the IFN-γ ELISPOT, a common immunoassay used to diagnose TB [10] and evaluate TB vaccine immune responses in humans and primates [11,12]; these data were then used to characterize the effect of the drug combinations on the Type 1 T helper (Th1) response to TB to understand whether they are beneficial or detrimental and perhaps direct how they could be improved. This evidence concerns the gene IFNG and tuberculosis.