HIF1A and neoplasm: These results indicated that long-term lower expression of HIF-1α was beneficial for suppressing the DNA damage repair and angiogenesis, further reversing the hypoxia-induced radio-resistance, which was consistent with results in Figure 6B. In all, both increasing oxygen levels and suppressing HIF-1α expression inside tumor tissues was simultaneously accomplished after multiple mild-hyperthermia stimulation based on the NIR-irradiated CuS-131I-PEG nanotheranostics.