TLR4 and Sepsis: LPS-mediated CD14 activates Src-Tyrosine kinase to phosphorylate caveolin-1 at Tyr in endothelial cells (14), Cav-1 specific [84].In sepsis-induced lung inflammation and injury, LPS triggers the association of Cav-1-pTyr14 with TLR4, thereby inducing NF-kappa B signaling for proinflammatory cytokines [85].