Sn-based nanomaterials could also induce apoptosis in breast cancer cells by mitigation of mitochondrial membrane potential, deactivation of catalase and superoxide dismutase activity, downregulation of PI3K/AKT/mTOR, overexpression of Bax/Bcl-2 signaling pathway [119], LDH leakage, as well as by the accumulation of cells in the sub-G1 phase [120]. The gene discussed is MTOR; the disease is breast cancer.