In Comparison of Sacubitril-Valsartan versus Enalapril on Effect on NT-proBNP in Patients Stabilized from an Acute Heart Failure Episode (PIONEER-HF) trial, ARNI group showed a higher tendency for symptomatic hypotension than ACE inhibitor group, although the difference was not statistically significant (ARNI: 15% vs. ACEi: 12.7%) [40]. The gene discussed is ACE; the disease is hydrops fetalis.