TNF and cancer: The predicted interaction network demonstrated that the interactions among the compounds, genes (CHEK2, FOS, MMP2, and TNF), and proteins studied (LC3 and NRF2) formed a biologically connected group (Figure 9) with more interactions than expected (observed/expected 41/16) (p < 0.001), a clustering coefficient equal to 0.839, and signaling pathways in cancer and regulation of cell death by apoptosis mainly associated with MAPK cell signaling (http://stitch.embl.de/cgi/network.pl?taskId=nv9TPmaTyMjt (accessed on 30 August 2022)).