For instance, Zhao et al. developed a cationic liposome-based nanoparticle that was loaded with miR-139-5p (miR-139-5p-HSPC/DOTAP/Chol/DSPE-PEG2000-COOH nanoparticles, MNPs) and surface that was decorated with EpCAM Apt (miR-139-5p-EpCAM Apt-HSPC/DOTAP/Chol/DSPE-PEG2000-COOH NPs, MANPs) for the CRC targeted treatment [184]. Here, EPCAM is linked to colorectal carcinoma.