CGA and neuroendocrine neoplasm: Although it is unlikely that this integrin has a receptor function for the circulating CgA polypeptides, considering its micromolar affinity, significant ligand-receptor interactions can possibly occur at sites where CgA is produced and, therefore, where this protein is present at high concentrations, such as in the microenvironment of wound keratinocytes and neuroendocrine secretory cells or in the microenvironment of neuroendocrine tumors.