In addition, the observation that the selective knockout of neuropilin-1 in cardiomyocytes and vascular smooth muscle cells leads to cardiomyopathy, increased propensity to heart failure, and reduced survival after myocardial infarction, suggests a role for neuropilin-1 in the pathogenesis of cardiovascular diseases [61]. The gene discussed is NRP1; the disease is myocardial infarction.