PLG and neoplasm: Intra-granular and/or extra-cellular proteolytic enzymes, such as furin, cathepsin L, prohormone convertase 1 and 2, thrombin and plasmin, can cleave the full-length CgA precursor (CgA1-439) at different sites to generate various biologically active fragments involved in the regulation of the innate immunity [5,6,7,8], cardiovascular system [9,10,11,12], metabolism [13,14,15], angiogenesis [16,17,18], tissue repair [19] and tumor growth [14,20,21].