TGFB1 and neoplasm: Remarkably, both αvβ6 and αvβ8 integrins (which are upregulated in many tumors and, in the case of αvβ8, also in tumor infiltrating Treg cells) can activate the latency associated peptide/TGFβ complex, through interactions of integrins with the RGD sites of the complex [73,83,92].