Remarkably, anti-PGPQLR373 antibodies capable of blocking the binding of CgA1-373 to neuropilin-1 can reduce the growth of pancreatic ductal adenocarcinoma in mice, which implicates an important role of neuropilin-1 as mediator of these effects [38]. The gene discussed is NRP1; the disease is pancreatic ductal adenocarcinoma.