NRP1 and neoplasm: As cleavage of plasma CgA in tumors and the consequent interaction with neuropilin-1 may represent an important mechanism for the regulation of tumor vascular biology and growth, the assessment of the extent of CgA fragmentation in cancer patients may have a prognostic value, whereas the development of compounds that target and block this ligand-receptor interaction (e.g., anti-PGPQLR373 monoclonal antibodies) may have a therapeutic value (see Figure 1B for a schematic representation of this concept).