CGA and pancreatic ductal adenocarcinoma: Other studies aimed at evaluating the extent and prognostic value of CgA cleavage in patients with pancreatic ductal adenocarcinoma, an aggressive cancer arising from the exocrine component of the pancreas [57,58,59], have shown that cleavage of the R373R374 bond and of other sites in the C-terminal region of circulating CgA is increased in these patients.