The role of DLCO in the evaluation of SSc-ILD patients may be highlighted: the decrease in DLCO correlates not only with the presence of neutrophilia or eosinophilia on BAL, but also with the BAL CD19 percentage count, inverted CD4/CD8 ratio, and CCL-18 concentrations. The gene discussed is CD8A; the disease is Increased total eosinophil count.