Certain recurrent genetic abnormalities, such as translocation t(9;22)-BCR-ABL1 fusion (Ph-positive ALL), hypodiploidy (< 44 chromosomes), BCR-ABL1-like (Ph-like) ALL, hyperdiploidy (51–67 chromosomes), t(v;11q23.3) (KMT2A-rearranged), t(12;21) (ETV6-RUNX1), t(1;19) (TCF3-PBX1) and t(5;14) (IL3-IGH) represent prognostic factors in children and adolescents with ALL [7,8]. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.