According to Rückert et al. [78] tumors generally show elevated Bcl-2 expression, so hepatic Bcl-2 upregulation in the DEN/2AAF group suggests that malignant cells were resistant to apoptosis, possibly due to increased gene copy numbers, transcription, and (or) translation of Bcl-2, as observed for other cancer-related genes [79,80]. The gene discussed is BCL2; the disease is cancer.