Taken together, targeting of the TLR4/NLRP3/NF-κB and GSK3β-Nrf2/HO-1 signaling axes may contribute to the inhibition of oxidative stress, neuroinflammation, and apoptosis, hence promoting neuroprotection and exerting potential therapeutic effects against PD. The gene discussed is NFKB1; the disease is Parkinson disease.