Bioinformatic analysis and a subsequent luciferase reporter assay established that miR-216a-5p binds and suppresses the expression of the translationally controlled tumor protein 1 (TPT1), an oncoprotein overexpressed in many human cancers that contributes to pancreatic tumor progression by regulating mTOR-dependent autophagy. The gene discussed is TPT1; the disease is pancreatic neoplasm.