Diagnosis is usually based on a combination of a set of imaging techniques, such as endoscopic ultrasonography (EUS), magnetic resonance imaging (MRI), and computed tomography (CT), the measurement of serological tumor markers (i.e., carbohydrate antigen 19-9 (CA19-9), osteopontin (OPN), carcinoembryonic antigen (CEA), S100A6, and macrophage inhibitory cytokine 1 (MIC-1)), the appearance of clinical features, and the “gold standard” histological examination [12,13,14]. The gene discussed is SPP1; the disease is neoplasm.