MAPK8 and cancer: The ACCD concept itself is novel in two aspects: (1) revealing that cancers and neurological disorders (including TBI) share a common mechanism of aberrant cell cycle re-entry, manifested as kinase/oncoprotein activation and tumor suppressor inactivation [1]; and (2) expanding the key “cell cycle players” from cyclin-dependent kinases (CDKs) and cyclins to Src family kinase (SFK), Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and other numerous kinases (Figure 1) [1].