For instance, Tang and his coworkers revealed that curcumin administration led to iron overload, glutathione (GSH) depletion, and lipid peroxidation, causing the downregulation of Recombinant Solute Carrier Family 7, Member 11, and Glutathione peroxidase 4 (GPX4) in lung cancer cells [148]. The gene discussed is GPX4; the disease is lung carcinoma.