SQSTM1 and steatosis: Lactucin and lactucopicrin target trifunctional enzyme subunit alpha (HADHA), disintegrin, metalloproteinase domain-containing protein 17 (ADAM17), Sequestosome-1 (SQSTM1), and lysosomal acid glucosylceramidase (GBA) genes to promote fatty acid oxidation, and then ameliorate FFA-induced steatosis [30].