In studies exploring the role of FN in preeclampsia, most researchers have investigated the association between FN and preeclampsia and indicated that FN is a useful predictor of preeclampsia development [9,10,32,33] Most related studies have shown elevated plasma and/or placental FN concentrations in preeclamptic patients, and this change could be detected as early as 16 weeks of gestation [10]. Here, FN1 is linked to preeclampsia.