CREB1 and influenza: Clustering of the ten most-enriched Reactome molecular pathways (Table S8) identified three major pathway clusters that may be affected by both influenza and Primula metabolite families: a cell death/cytolysis-related cluster, the inflammasome pathway and a signaling pathway that involves p90 ribosomal S6 kinase (RSK) and its downstream target CREB (Figure 7B).