CD8A and neoplasm: Moreover, T cell distribution was markedly altered by the above therapies; the number of infiltrated CD8+ T cells was higher in the tumor tissue after treatment with siTGF-β1-αPDL1-PEG-PCL-NPs compared with the siTGF-β1-PEG-PCL and αPDL1 + siTGF-β1-PEG-PCL groups (Figure 5B).