The siTGF-β1-PEG-PCL, αPDL1 + siTGF-β1-PEG-PCL and siTGF-β1-αPDL1-PEG-PCL groups showed significantly enhanced CD8+ T cell infiltration into the tumor, converting the immune-excluded phenotype into the immune-inflamed phenotype (Figure 5A). Here, CD8A is linked to neoplasm.