BMP7 and chronic kidney disease: Using two genetic models for chronic kidney disease and fibrosis (mice deficient in the α3-chain of type IV collagen and MRL/MpJlpr/lpr lupus mice), Zeisberg et al. showed that treatment with recombinant human BMP-7 reduced the expression of profibrotic molecules, including type I collagen and fibronectin in renal fibroblasts, and induced active matrix metalloproteinase-2 expression, which mediates removal of fibrotic matrix [88].