Withalongolide A triacetate (WGA-TA) is a safe biosynthetic withanolide which inhibits Hsp90 client proteins by disruption of the Hsp90 hetero chaperone complex through disrupting the co-chaperone cdc37 from Hsp90, leading to the induction of apoptosis and the inhibition of several regulatory pathways including PI3K/Akt/mTOR, which has been implicated in cisplatin resistance and HNSCC progression [15]. This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.