In the present study, we evaluate treatment responses including cell viability, cellular proliferation, epithelial to mesenchymal transition (EMT), apoptosis, cellular pathways classically implicated in carcinogenesis and cisplatin resistance (i.e., PI3K/Akt/mTOR pathway), and cancer stem cell properties of WGA-TA and cisplatin combination treatment as a viable safe treatment option for HNSCC. The gene discussed is MTOR; the disease is head and neck squamous cell carcinoma.