NOS2 and ischemia: In conclusion, in our study, we found that CA promoted the migration of antioxidant regulator Nrf2 from the cytoplasm to the nucleus and that Nrf2 into the nucleus promotes the increased expression of antioxidant proteins such as HO-1and SOD, these antioxidant proteins can resist the damage of cells and brain tissue caused by excessive reactive oxygen species and inflammatory factors such as iNOS produced during ischemia.