Considering the importance of PPARα in the context of the effect of this transcription factor on the efficacy of applied reduction diets and the effectiveness of weight reduction after exercise, it should be noted that the activation of PPARα stimulates weight reduction in rodents [151], but that this effect has not been clearly confirmed in humans—keeping in mind that studies that do not confirm this phenomenon have so far been conducted mainly in patients with type 2 diabetes [152,153], and that there are no such studies in healthy humans. Here, PPARA is linked to type 2 diabetes mellitus.