Similar doses of crocin (i.p., 25 or 50 mg/Kg b.w.)also exerted neuroprotective effects in a rat model of MK-801-elicited schizophrenia by modulating the expression of silent information regulator-1 (SIRT1) and brain-derived neurotrophic factor (BDNF). This evidence concerns the gene BDNF and schizophrenia.