Furthermore, we found in the present study that IL-1β, IL-6R, IL-6, IL-17, and IL-23, proliferative markers of lymphocytes and regulatory mediators of autoimmune disorders, were also significantly reduced by the OL-EAE treatment when compared to the mice in the CIA-control group, suggesting that OL-EAE produces an antinociceptive effect in the CIA model. Here, IL1B is linked to autoimmune disease.