To the best of our knowledge, this is the first study to show that OL-EAE protects against bone and cartilage degradation and inflammation during the progression of RA in CIA mice by reducing the release of inflammatory mediators (NF-κB, COX-2 STAT3, PTEN, and RANKL) and pro-inflammatory cytokines (IL-1β, IL-6R, IL-6, IL-17, and IL-23) and by increasing the expression of miR-28 and miR-199. This evidence concerns the gene STAT3 and rheumatoid arthritis.