NR1H4 and obesity due to melanocortin 4 receptor deficiency: BCFA are associated with obesity, insulin resistance and development of T2D; Bacteroides spp. may improve the efficiency of BCFA degradation  Ass. With ↑faecal SCFA, plasma BCFA, plasma TMAO, plasma total bile acids and plasma LPS. MetS and NAFLD seem to occur via intestinal FXR