Driver of enterotype 1; is a mucus-forager with lack of DF B. thetaiotaumicron regenerates NAD+; reduced S-BCAA and alleviated diet-induced weight-gain and obesity in mice. Influences Muc2 and goblet cell differentiation. Produces butyrate via the succinate pathway. The gene discussed is MUC2; the disease is obesity due to melanocortin 4 receptor deficiency.