Four genetic variants have been most commonly described in association with NAFLD: patatin-like phospholipase domain-containing protein 3 (PNPAL3), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulatory protein (GCKR) and membrane-bound O-acyltransferase domain-containing 7 (MBOAT7). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.