INS and obesity due to melanocortin 4 receptor deficiency: In light of this preliminary evidence, the revised protein-sparing diet is proposed as an impact treatment not only in the management of any classes of obesity, also as a possible integrative treatment for bariatric surgery but especially for obese diabetic patients, where treatment can lead to a significant reduction in hypoglycemic therapy through the possible restoration of the function of the pancreatic beta cells and normal insulin sensitivity.